evaluation of fcγriiib-na1/na2 polymorphism in visceral leishmaniasis

conclusions: according to our results, it is likely that the increased frequency of the fcγriiib-na1/na2 genotype is associated with impaired immune responses against vl and its subsequent clearance from the patient. results: our results indicated that polymorphisms within the fcγriiib gene (that lead to the expression of the na1/na2 isoforms) are significantly associated with vl. the results demonstrated that the genotype heterozygotic for fcγriiib-na1/na2 expression was significantly increased in vl patients, group 1 when compared to groups 2 and 3. conversely, there is a decrease in homozygous na1 and na2 genotypes in vl patients; however, the overall frequency of na1 and na2 alleles appear similar across the three cohorts examined. objectives: the main aim of this study was to evaluate the fcγriiib-na1/na2 polymorphism in the fcγriiib gene of vl patients in comparison to healthy controls. patients and methods: in this cross-sectional study, three groups; 54 seropositive patients with clinical presentation of vl (group 1), 104 seropositive patients without clinical presentation (group 2), and 104 healthy controls (group 3) were evaluated with respect to the fcγriiib-na1/na2 polymorphism using a pcr-ssp method. the titration of anti-leishmania antibodies was analyzed using an immunoflorescence technique. background: several lines of evidence demonstrating that innate and adaptive immunity play important roles in the defense against visceral leishmaniasis (vl). a polymorphism within the fcγriiib gene can lead to the expression of three variants of na1, na2, and the combined one (na1/na2) which alters affinity of igg to its receptor.